Tang 2004.

Methods	Computer‐generated random numbers; sealed envelopes, opened at recruitment.
Participants	220 pregnant women (group I: 112, group II: 108) Inclusion criteria: 12‐20 weeks gestation. Exclusion criteria: regular use of prescription drugs, IUD in utero, nursing mothers, multiple pregnancies, heavy smokers.
Interventions	Group I: Vaginal administration 400 μg misoprostol every 3h, max 5 doses in 24 hours. Group II: Sublingual administration 400 μg misoprostol every 3h, max 5 doses in 24 hours.
Outcomes	Primary outcome: success rate at 48 hours. Secondary outcomes: success rate at 24 hours, side‐effects.
Notes	Definition of abortion: expulsion of the fetus and placenta. If the placenta was incomplete, evacuation of the uterus was performed. No major complications occurred.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ adequate
Blinding? All outcomes	High risk
Free of other bias?	Low risk	No statistically significant differences between the groups in terms of maternal age, gestational age and parity.