Tang 2005.
Methods | Computer‐generated randomisation sequence; sealed, sequentially numbered treatment packs, which were filled and labelled in accordance with the list of randomisation. | |
Participants | 118 women (group I: 58, group II: 60) Inclusion criteria: >18 years, 12‐20 weeks gestation. Exclusion criteria: regular use of prescription drugs, IUD in utero, nursing mothers, multiple pregnancies, heavy smokers. |
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Interventions | all: mifepristone 200mg orally, 36‐48h later: Group 1: misoprostol 400 μg sublingual and 2 placebo tablets orally every 3 hrs, max 5 d; Group 2: misoprostol 400 μg orally and 2 placebo tablets sublingually every 3 hrs, max 5 d. |
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Outcomes | Primary outcome: success rate at 24 h. Secondary outcomes: induction‐to‐abortion interval, side‐effects. |
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Notes | Definition of abortion: not specified. If the placenta was incomplete, evacuation of the uterus was performed. No major complications occurred. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Low risk | A ‐ adequate |
Blinding? All outcomes | Low risk | Blinding for participants and clinicians. |
Free of other bias? | Low risk | No statistically significant differences between the groups in terms of maternal age, gestational age and parity. |