Wong 1998.
Methods | Randomisation schedule, (sealed) envelopes bearing the subject number and allocation were prepared as described by Meinert. The envelopes were opened only when recruited. | |
Participants | 140 pregnant women (group I: 70, group II: 70) Inclusion criteria: healthy women, age 16‐40 years, 14‐20 weeks gestation. Exclusion criteria: regular use of prescription drugs, cardiac disorders, IUD in situ, missed abortion, multiple pregnancy, nursing mothers. |
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Interventions | Group I: misoprostol 400 μg vaginally every 3 hours, max 5d. Group II: gemeprost 1 mg vaginally every 3 hours, max 5d. |
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Outcomes | Primary outcomes: induction‐abortion interval, rates of successful abortion (within 24 h), complete abortion. Secondary outcomes: side‐effects. |
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Notes | Definition of abortion: expulsion of fetus. If the placenta was incomplete, evacuation of the uterus was performed under general anaesthesia. No major complications reported. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Low risk | A ‐ adequate |
Blinding? All outcomes | High risk | |
Free of other bias? | Low risk | No statistically significant differences between the groups in terms of maternal age, gestational age and parity. |