Wong 2000.

Methods	Randomisation schedule, envelopes bearing the subject number and allocation were prepared as described by Meinert. The envelopes were opened only when recruited.
Participants	148 pregnant women (group I: 74, group II: 74) Inclusion criteria: healthy women, 14‐20 weeks' gestation. Exclusion criteria: regular use of prescription drugs, IUD in situ, missed abortion, multiple pregnancy, nursing mothers.
Interventions	All: vaginal misoprostol 400 μg Group I: every 3 hours; Group II: every 6 hours.
Outcomes	Primary outcomes: induction to abortion interval, abortion within 24 hours, complete abortion. Secondary outcomes: side‐effects.
Notes	Definition of abortion: expulsion of fetus and placenta. If the placenta was incomplete, evacuation of the uterus was performed under general anaesthesia. No major complications reported.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ adequate
Blinding? All outcomes	High risk
Free of other bias?	Low risk	No statistically significant differences between the groups in terms of maternal age, gestational age and parity.