TABLE 1.
Clinical Features of the Study Cohorts (Upper Panel: 21,296 Apparently Healthy Individuals From the Ca’ Granda‐2018 Cohort, Who Were Included in the Study; Lower Panel: 745 Individuals From the Liver‐Bible‐2020 Cohort)
| Ca’ Granda‐2018 Cohort, Whole Population | Males (n = 13,741, 64.5%) | Females (n = 7,555, 35.5%) | P Value |
|---|---|---|---|
| Age, years | 41.3 (12.9) | 37.8 (13.6) | <0.0001 |
| BMI, kg/m2 | 24.9 (3.2) | 23.0 (3.6) | <0.0001 |
| Obesity, yes | 957 (7.0) | 408 (5.4) | <0.0001 |
| Glucose, mg/dL | 86 (10) | 83 (12) | <0.0001 |
| Impaired fasting glucose, yes | 323 (2.4) | 186 (2.5) | 0.60 |
| Total cholesterol, mg/dL | 184 (35) | 182 (33) | <0.0001 |
| Triglycerides, mg/dL | 97 (57) | 77 (38) | <0.0001 |
| Arterial hypertension | 4,229 (30.9) | 1,007 (13.4) | <0.0001 |
| ALT, U/L | 26.2 (13.3) | 18.9 (13.5) | <0.0001 |
| HBsAg, positive | 251 (1.8) | 247 (3.3) | <0.0001 |
| Anti‐HCV Ab, positive | 254 (1.9) | 246 (3.3) | <0.0001 |
| First‐time donors | 1,902 (13.8) | 1,496 (19.8) | <0.0001 |
| Ca’ Granda‐2018 Cohort, Population at Low Risk for Liver Disease | Males (n = 4,855, 64.5%) | Females (n = 4,340, 35.5%) | P Value |
|---|---|---|---|
| Age, years | 37.1 (12.9) | 35.8 (13.0) | <0.0001 |
| BMI, kg/m2 | 22.7 (2.1) | 21.4 (2.0) | <0.0001 |
| Obesity, yes | 0 | 0 | 1 |
| Glucose, mg/dL | 83 (7) | 81 (7) | <0.0001 |
| Impaired fasting glucose, yes | 0 | 0 | 1 |
| Total cholesterol, mg/dL | 172 (30) | 175 (28) | <0.0001 |
| Triglycerides, mg/dL | 73 (26) | 67 (24) | <0.0001 |
| Arterial hypertension | 957 (19.9) | 366 (8.5) | <0.0001 |
| ALT, U/L | 23.7 (12.8) | 18.0 (8.4) | <0.0001 |
| HBsAg, positive | 0 | 0 | 1 |
| Anti‐HCV Ab, positive | 0 | 0 | 1 |
| First‐time donors | 786 (16.4) | 883 (20.3) | <0.0001 |
| Liver Bible‐2020 Cohort | Males (n = 632, 84.8%) | Females (n = 113, 15.2%) | |
|---|---|---|---|
| Age, years | 53.8 (6.4) | 53.7 (6.2) | 0.88 |
| BMI, kg/m2 | 28.5 (2.9) | 29.0 (3.5) | 0.21 |
| Obesity, yes | 140 (22.2) | 33 (29.2) | 0.12 |
| Glucose, mg/dL | 96 (13) | 94 (13) | 0.15 |
| Impaired fasting glucose, yes | 34 (5.4) | 14 (12.5) | 0.010 |
| Total cholesterol, mg/dL | 200 (31) | 211 (32) | 0.001 |
| Triglycerides, mg/dL | 172 (94) | 155 (67) | 0.018 |
| Arterial hypertension | 440 (69.6) | 82 (72.6) | 0.58 |
| ALT, U/L | 31.5 (13.9) | 24.0 (13.9) | <0.0001 |
Data are shown as mean (SD) or frequency (%). P values were determined at univariate logistic regression models.