TABLE 3.

Independent Determinants of Serum ALT Levels (log U/L) in the Whole Ca’ Granda‐2018 Cohort of 21,296 Healthy Individuals, and in Males/Females Separately

	Estimate	SEM	P Value
Overall Cohort, n = 21,296
Sex, F	−0.103	0.003	6*10−238
Age, years	−0.001	0.002	2*10−10
BMI, kg/m2	+0.022	0.001	2*10−159
Glucose, 10 mg/dL	+0.010	0.006	0.003
Triglycerides, 10 mg/dL	+0.004	0.003	5*10−16
Total cholesterol, 10mg/dL	+0.010	0.001	2*10−46
Ferritin, log ng/mL	+0.083	0.003	2*10−117
Arterial hypertension, yes	+0.012	0.003	0.0002
Physical activity, moderate/severe	+0.007	0.002	0.013
HBsAg or anti‐HCV Ab, positive	+0.004	0.008	0.59
Recreational drug use, yes	−0.011	0.004	0.019
Regular alcohol drinking, yes	−0.006	0.004	0.16
Males, n = 13,741
	Estimate	SEM	P Value
Age, years	−0.004	0.000	4*10−34
BMI, kg/m2	+0.029	0.001	1*10−153
Glucose, mg/dL	+0.001	0.000	0.0001
Triglycerides, mg/dL	+0.0005	0.0004	1*10−16
Total cholesterol, mg/dL	+0.001	0.000	3*10−46
Ferritin, log ng/mL	+0.078	0.004	3*10−70
Arterial hypertension, yes	+0.012	0.003	0.001
Physical activity, moderate/severe	+0.001	0.003	0.79
HBsAg or anti‐HCV Ab, positive	+0.018	0.011	0.13
Recreational drug use, yes	−0.015	0.005	0.005
Regular alcohol drinking, yes	+0.004	0.005	0.50
Females, n = 7,555
	Estimate	SEM	P Value
Age, years	−0.001	0.003	3*10−7
BMI, kg/m2	+0.014	0.001	2*10−28
Glucose, 10 mg/dL	+0.000	0.000	0.65
Triglycerides, 10 mg/dL	+0.000	0.000	0.97
Total cholesterol, 10 mg/dL	+0.010	0.002	3*10−7
Ferritin, log ng/ml	+0.070	0.006	2*10−29
Arterial hypertension, yes	+0.010	0.006	0.097
Physical activity, moderate/severe	+0.018	0.005	9*10−5
HBsAg or anti‐HCV Ab, positive	+0.004	0.008	0.75
Recreational drug use, yes	−0.006	0.008	0.48
Regular alcohol drinking, yes	−0.009	0.005	0.098

P values were determined at multivariate generalized linear models, adjusted for the confounders specified in the table.