FIG. 6.

Analysis of HBV RNA and HBcrAg dynamics in the REP 401 study. HBV‐DNA dynamics (top row) are provided for comparison with HBV RNA (middle row) and HBcrAg (bottom row). Individual responses for all control and experimental participants during the first 48 weeks of therapy (left), for all participants during NAP combination therapy (middle) and maintaining HBV DNA < 2,000 IU/mL after removal of all therapy (left) are provided. The number of participants maintaining HBV DNA/HBV RNA < LLOQ or TND and HBcrAg < LLOQ during follow up are indicated on the right. Treatment paradigms are indicated at the top (see also Fig. 2A). HBV DNA, HBV RNA, and HBcrAg responses in participants experiencing viral rebound during follow‐up are presented in Supporting Fig. S2. HBV‐DNA responses were previously published.^{( 19 )}