Figure 1.

Plasma P-tau217 levels independently predict longitudinal tau accumulation in non-demented individuals. Predicted trajectories for temporal tau accumulation (z-scores) in relation to baseline plasma P-tau217. (A) The models were fit using continuous P-tau217 values but for illustration purposes the plots show the trajectories for individuals with high, medium and low plasma P-tau217 tertiles. (B) The voxel-wise analyses using longitudinal tau images showed a positive correlation between plasma P-tau217 and increased tau accumulation in temporal and parietal areas, after FDR corrections.