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. 2021 Jun 2;144(9):2826–2836. doi: 10.1093/brain/awab163

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Plasma P-tau217 and NfL levels independently predict longitudinal brain atrophy in non-demented individuals. Predicted trajectories for temporal cortical thickness and hippocampal volumes (z-scores) in relation to baseline plasma P-tau217 and plasma NfL. (A–C) The models were fit using continuous P-tau217 and NfL values but for illustration purposes the plots show the trajectories for individuals with high, medium and low plasma P-tau217 tertiles for (A) temporal cortical thinning and (B) hippocampal volume loss as well as (C) individuals with high, medium and low plasma NfL tertiles. (D) The voxel-wise analyses showed a positive correlation between plasma P-tau217 and longitudinal brain atrophy in parietal and occipital areas, after FDR corrections. Plasma NfL did not show significant results in the voxel-wise analyses, after adjusting for multiple comparisons.