Figure 3.

Relationship between MTL subregional tau SUVR and atrophy. (A) Relationships in cognitively unimpaired individuals and (B) in patients with MCI. Correlation matrices show the relationship between subregional measures of tau SUVR (rows) and atrophy measures (columns). Relationships lying on the diagonal (highlighted in blue) indicate local relationships between a given subregions tau SUVR and local thickness or volume. Relationships off the diagonal indicate distant effects, where tau SUVR in one region was associated with atrophy in another region. Dark green represents multiple regression models that are significant at P_FDR < 0.005, while light green indicate significance at P_FDR < 0.05. All regression models were corrected for age, sex and continuous amyloid-β PET SUVR in the cortical composite region. Regression models including volumetric measures (anterior and posterior hippocampus) were additionally corrected for intracranial volume. A35 = Brodmann area 35; A36 = Brodmann area 36; Aβ = amyloid-β; CU = cognitively unimpaired; ERC = entorhinal cortex; IPC = inferior parietal cortex; ITC = inferior temporal cortex; MTC = middle temporal cortex; PHC = parahippocampal cortex; PRE = precuneus; RSC = retrosplenial cortex.