Figure 5.

Changes in functional connectivity between the MTL and regions in the anterior-temporal and posterior-medial system in cognitively unimpaired individuals. (A) Network component of reduced functional connectivity with increasing tau-PET signal in Brodmann area 35 and (B) the entorhinal cortex. (C) Subcomponents of A that are significantly associated to delayed recall memory performance. Line width and colour in the connectograms are proportional to the number of links between regions of interest as indicated in the corresponding scale. A35 = Brodmann area 35; A36 = Brodmann area 36; Aβ = amyloid-β; CU = cognitively unimpaired; ERC = entorhinal cortex; IPC = inferior parietal cortex; ITC = inferior temporal cortex; MTC = middle temporal cortex; PHC = parahippocampal cortex; PRE = precuneus; RSC = retrosplenial cortex.