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. 2021 Oct 27;3(4):lqab097. doi: 10.1093/nargab/lqab097

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© The Author(s) 2021. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Drug combinations suggested by subsystems identified by ParsVNN. (A) Functional organization of subsystems in BRCA-specific ParsVNN model. (B) Genes in subsystems 1, 2 and 11 and the corresponding drugs targeting those genes. Three drug combinations are suggested by parallel pathway inhibition theory. (C) The average drug synergy scores of the three drug combinations on four different breast cancer cell lines extracted from DrugCombDB (73). Comb1 is synergistic on KPL1. Comb2 is synergistic on T-47D and OCUBM. Comb3 is synergistic on KPL1, MDAMB436 and OCUBM.