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. 2021 Aug 12;38(11):5134–5143. doi: 10.1093/molbev/msab240

Fig. 4.

Fig. 4.

Probable mechanisms of circular permutation between SH3 and OB domains. (A) Schematic representation of the proposed mechanism of the circular permutation of an OB core topology to a SH3 topology. Inset 1: Comparison of the core of SH3 and OB domains in uL2 using the MSA of uL2(SH3) core in native order and the MSA of circularly permuted uL2(OB). (B) Predicted structure of the circular permutation of the core of uL24(SH3). (C) Schematic representation of the proposed mechanism for the circular permutation of a SH3 domain topology that results in an OB domain topology. (D) Predicted structure of the circular permutation of the core of uL2(OB). Comparison between uL24(SH3) and bS1(OB4) using MSAs that account for a circular permutation. Inset 3: Comparison between uL24(SH3) and bS1(OB4) using MSAs in native order. Dotted lines indicate elements that are lost or highly modified.