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. 2021 Oct 30;19:355. doi: 10.1186/s12951-021-01101-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Anti-tumor efficacy of TB/PTX@RTK micelles in vivo. A Representative images of tumor-bearing mice and harvested tumors after various treatments. Scale bar: 1 cm. B Tumor volume at indicated time points after different treatments (n = 5 per group). Data represent mean ± SD. C Tumor weight at 21 days after different treatments. Data represent mean ± SD. D H&E staining for histological changes in Hep 1–6 tumor tissues after different treatments (upper row). Ki-67 expression detected by IHC in tumor tissues sections after different treatments (middle row). TUNEL assay for apoptosis levels in Hep 1–6 tumor tissues after different treatments (lower row). Scale bar: 20 μm. E Survival curves of Hep 1–6 tumor-bearing C57BL/6 mice in different treatment groups (n = 8 per group). *P < 0.05, ***P < 0.001