Fig. 8.

Hierarchical chromatin organization in the nucleus—a simplified view. The negatively charged 10-nm fiber is compacted into chromatin domains (e.g., topologically associating domain [TAD]/contact domain/loop domain) [136–139]. The domains are clustered over long distances to form chromatin compartments [147]. Compartments generally represent a transcriptionally active chromatin state (compartment A) and an inactive chromatin state (compartment B). A single interphase chromosome is occupied in a chromosome territory (highlighted as different colors) [219]. This illustration was

reproduced with modifications from [220].