Table 2.

Delivery of RNA by MSC-EXOs

RNA	Exosomes origin	Loading methods	Administration route	Model	Aim	References
miR-122	AMSC	Transfection	Intra-tumor injection	Mice	Enhance HCC chemosensitivity	[34]
miRNA-181-5p	AMSC	Transfection	Intrasplenic injection	Mice	Prevent liver fibrosis	[67]
microRNA-584	BMSCs	Transfection	Local injection	Mice	Reduce glioma activity	[62]
miR-132	BMSCs	Electroporation	Local injection	Mice	Promote angiogenesis	[107]
LNA-anti-miR-142-3p	BMSCs	Electroporation	Intravenous injection	Mice	Reduce tumorigenicity of breast cancer	[88]
miR-379	BMSCs	Transfection	Intravenous injection	Mice	Reduce breast cancer activity	[72]
miR-124	WJMSCs	Transfection	In vitro experiment	GBM cancer cells	Reduce glioblastoma multiform cells activity	[73]
miR-133b	BMSCs	Transfection	Intravenous injection	Mice	Neuroprotective role	[64]
miR-145-5p	HucMSCs	Transfection	Intra-tumor injection	Mice	Inhibit pancreatic ductal adenocarcinoma	[91]
miR-675	HucMSCs	Transfection	Local injection	Mice	Treat aging-induced vascular dysfunction	[110]
miR-126	BMSCs	Transfection	In vitro cell experiment	N/A	Ameliorate hypoxia/reoxygenation-injured ECs	[108]
miR-644-5p	BMSCs	Transfection	Intravenous injection	Cisplatin-induced POF mouse mode	Inhibit ovarian granulosa cell apoptosis	[74]
miR-34a	BMSC	Transfection	Intravenous injection	Mice	Reduce GBM activity	[93]
miR-29b	BMSC	Transfection	Intravenous injection	Mice	Repair spinal cord injury in rats	[63]
tsRNA-10277	BMSC	Transfection	In vitro cell experiment	N/A	Enhance osteogenic differentiation ability of dexamethasone-induced BMSCs	[75]
miR-126	BMSC	Transfection	Intravenous injection	Rats	Promote repair after spinal cord injury	[68]
MiR-29	BMSC	Transfection	Local injection	Rats	Potential treatments for AD	[96]
miR-499	BMSC	Electroporation	Intratumorally injected	Mice	Inhibit endometrial cancer growth and metastasis	[76]
miR-544	BMSCs	Transfection (incubate together)	Intravenous injection	Rats	Promote repair after spinal cord injury	[97]
miR-199a	AMSCs	Transfection	Intravenous injection	Mice	Improve HCC chemosensitivity	[66]
miR-29a	BMSCs	Transfection	Intravenous injection	Mice	Promote angiogenesis and osteogenesis	[112]
LNA-antimiR-142-3p	BMSCs	Electroporation	In vitro cell experiment	Mice	Reduce the tumorigenicity of breast cancer stem cells in vivo	[89]
miRNA-126-3p	HucMSCs	Transfection	In vitro cell experiment and intravenous injection	Mice	Enhance endothelial function and attenuate vein graft neointimal formation	[77]
miR-326	HucMSC	Transfection	Intravenous injection	Mice	Relieve DSS-induced IBD	[78]
miR-19a/19b	BMSCs	Transfection	Intravenous injection	Mice	Mitigate the damage of myocardial infarction	[70]
MiR-17–92	BMSCs	Transfection	Intravenous injection	Mice	Enhance axon-myelin remodeling and motor electrophysiological recovery after stroke	[65]
miR-124	BMSCs	Transfection	Subcutaneous injection	Mice	Treatment of pancreatic tumors	[71]
miR-124	HADMSCs	Transfection	In vitro cell experiment	M17 human NB cell line	Therapy for NB cancer	[79]
miR-214	BMSCs	Transfection	Intracerebroventricular injection	Rats	Neuroprotection against cerebral	[80]
miR-381	ADMSC	Electroporation	In vitro cell experiment	MDA-MB-231 cells	Inhibit triple-negative breast cancer aggressiveness	[81]
aiR-34a	Dental pulp MSCs (DPSCs)	Transfection (Lentiviral miR-34a transduction)	In vitro cell experiment	MDA-MB-231 cells	Repress proliferation of breast carcinoma cells	[82]
miR-135B	BMSCs	Transfection	Articular cavity injection	OA rat model	Attenuate the damage of cartilage tissues	[83]
miR-155-5P	Synovial MSCs (SMSCs)	Transfection	Articular cavity injection	OA rat model	OA therapy	[84]
miR-126	BMSCs	Transfection	In vitro cell experiment	Human umbilical vein endothelial cells	Pro-angiogenic potential	[85]
MicroRNA-let7c	BMSCs	Lentiviral transduction	Administered intravenously	Rats	Attenuate renal fibrosis	[86]
PTEN-siRNA	BMSCs	Incubated	Intranasal injection	Rats	Promote recovery for SCI	[98]
miR-21	HucMSC	Transfection	In vitro cell experiment	β-cells	Treatment of diabetes	[100]
miR-375	BMSCs	Transfection	In vitro cell experiment	β-cells	Treatment of diabetes	[101]
miR-125a	ADMSC	Transfection	Intravenous injection	Rats	Diabetic nephropathy	[104]
miR-126	HucMSC	Transfection	Local injection	Rats	Diabetic eye diseases	[105]
lncRNA H19	BMSCs	Transfection	Local injection	Rats	Diabetic foot ulcer	[106]

N/A, not applicable