Table 2.

Unadjusted and multivariate analyses for overall survival (3-category stroma-immune score)

	Development group			Internal validation group			External validation group
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Unadjusted stratified Cox model
Stroma-immune score
Low	1			1			1
Intermediate	0.48	0.27–0.84	0.011	0.60	0.30–1.18	0.140	0.31	0.10–0.94	0.039
High	0.30	0.16–0.58	< 0.001	0.40	0.19–0.85	0.017	0.40	0.13–1.22	0.110
Multivariable stratified Cox model
Stroma-immune score
Low	1			1			1
Intermediate	0.45	0.25–0.79	0.006	0.60	0.30–1.19	0.15	0.34	0.11–1.06	0.062
High	0.35	0.18–0.66	0.001	0.43	0.20–0.92	0.029	0.40	0.13–1.23	0.110
TNM stage
II	1			1			1
III	3.25	1.76–6.00	< 0.001	2.63	1.40–4.95	0.003	1.77	0.75–4.20	0.195
Age	1.04	1.01–1.06	0.007	1.02	0.99–1.04	0.15	1.03	1.00–1.07	0.072

HR hazard ratio, CI confidence interval, TNM tumor-node-metastasis