Table 3.

Unadjusted and multivariate analyses for overall survival (2-category stroma-immune score)

	Development group			Internal validation group			External validation group
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Unadjusted stratified Cox model
Stroma-immune score
Low	1			1			1
High	0.39	0.24–0.63	< 0.001	0.49	0.28–0.88	0.017	0.35	0.15–0.83	0.018
Multivariable stratified Cox model
Stroma-immune score
Low	1			1			1
High	0.40	0.24–0.66	< 0.001	0.52	0.29–0.93	0.027	0.37	0.15–0.89	0.027
TNM stage
II	1			1			1
III	3.31	1.80–6.09	< 0.001	2.68	1.42–5.04	0.002	1.79	0.76–4.22	0.184
Age	1.04	1.01–1.06	0.006	1.02	0.99–1.04	0.151	1.03	1.00–1.07	0.072

HR hazard ratio, CI confidence interval, TNM tumor-node-metastasis