Table 2.

Adverse reactions of pirfenidone treatment

Study ID	Main adverse reactions	Major adverse reactions leading to interruption of treatment
Azuma 2005	Photosensitivity (43.8%), gastrointestinal discomfort (30.1%), anorexia (31.5%)	Photosensitivity (5 cases), vomiting, fever, abnormal liver function, dizziness, facial paralysis, hepatocellular tumor (1 case each)
CAPACITY 2011	Nausea (36.0%), skin rash (32.0%)	Nausea (36.0%), rash (28.1%), headache (25.9%), cough (25.2%), diarrhea (22.3%)
Huang 2015	Skin rash (39.5%), nausea (5.26%), diarrhea (7.89%)	NA
King 2014	Nausea (36.0%), rash (28.1%), headache (25.9%), cough (25.2%), diarrhea (22.3%)	Acute exacerbation of IPF, elevated liver enzymes, pneumonia (both 1.1%)
Lei 2018	Photosensitivity, loss of appetite, fatigue	NA
Li 2015	NA	NA
Li 2016	Gastrointestinal reaction, abnormal liver function	NA
Taniguchi 2010	Photosensitivity (51.4%), nasopharyngitis (49.5%), anorexia (16.5%)	Photosensitivity (2.8%), lung cancer (1.8%), fever (1.8%), respiratory failure (1.8%)