Fig. 8.

The biological significance of RS. a, b Differences in RS between the two stem cell subtypes in a the training and b validation sets (all P < 2.22e − 16). c, d Two stem cell subtypes were distinguished by well-defined biological signatures curated from MSigDB database in c the training and d validation sets. Statistical significance: *P < 0.05; **P < 0.01; ***P < 0.001. e, f The correlation between RS and TME infiltration cells using Spearman’s analysis in e the training and f validation sets. Negative correlation: blue; positive correlation: red. P < 0.05