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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: NMR Biomed. 2020 Sep 18;34(5):e4411. doi: 10.1002/nbm.4411

Figure 3.

Figure 3.

Optimized in vivo MRS detection of 2HG from mutant-IDH glioma patients using (A) J-difference editing 3D MEGA-LASER sequence (TR/TE = 1600/68 ms, matrix 10 × 10 × 10, FOV=200 × 200 × 200 mm3, and acquisition time = 9.5 min; reproduced with permission from Reference99); (B) long echo 2D PRESS (TR/TE = 1300/97 ms, matrix 16 × 16, FOV = 160 × 160 mm2, slice 15 mm, and acquisition time = 10 min; reproduced with permission from Reference96); and (C) 2D COSY-LASER (TR/TE = 1500/30 ms, voxel 3.0 × 3.0 × 3.0 cm3, 64 t1 increments, acquisition time = 11.5 min; reproduced with permission from Reference97) at 3 T.