Table 2.
Mean synovial inflammatory and cartilage biomarkers of yearling horses before (day 0) and after 84 d of receiving either no supplementation (CON; n = 9) or 21 g Saccharomyces cerevisiae fermentation product (SCFP; n = 10) per day
| Synovial biomarker1 | Diet | Day 0 | Day 84 | SEM | P-value | ||
|---|---|---|---|---|---|---|---|
| Diet | Time | Diet × Time | |||||
| PGE2, pg/mL2 | CON | 454.07 | 460.59 | 49.94 | 0. 79 | 0.19 | 0.25 |
| SCFP | 392.02 | 496.16 | |||||
| CPII, ng/mL | CON | 955.38 | 993.20 | 114.24 | 0.46 | 0.76 | 0.83 |
| SCFP | 866.60 | 873.43 | |||||
| C2C, ng/mL | CON | 228.86 | 161.31* | 9.96 | 0.41 | <0.01 | 0.13 |
| SCFP | 226.70 | 182.52* | |||||
| CPII:C2C, AU | CON | 4.07 | 5.76* | 0.51 | 0.37 | <0.01 | 0.44 |
| SCFP | 3.84 | 4.94* |
1C2C, collagenase cleavage neopeptide; CPII, carboxypropeptide of type II collagen; PGE2, prostaglandin E2.
2Synovial concentrations differed between CON and SCFP at day 0, so day 0 was included as a covariate in statistical analyses.
*Within row, day 0 differs from day 84 (P < 0.05).