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Simvastatin reduced c-Myc expression, a downstream signaling target of β-catenin, in human leiomyoma cells. Human leiomyoma cells (HuLM) and primary cells were treated with simvastatin (1uM) for 48 hours. A, Simvastatin significantly reduced the mRNA expression of c-Myc in HuLM cells. B, Simvastatin reduced the protein expression of c-Myc in primary cells as seen in immunohistochemistry. The band was not seen when Western blotting was attempted.
