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. 2021 Oct 7;3(4):fcab237. doi: 10.1093/braincomms/fcab237

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Example of regional distribution of non-invasive and complementary MRI markers of cortical involvement: cortical thickness, T1/T2 ratio and neurite dispersion. Notice the similarity in the cortical distribution of cortical thickness, T1/T2 ratio and neurite dispersion around the frontal, parietal and temporal cortices across markers. (A) The cortical distribution of these markers in a 36-year-old healthy individual. (B) The cortical distribution of these markers of an age-matched multiple sclerosis patient at disease onset (EDSS: 2; disease duration: 2 years).