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. 2021 Jun 23;224(8):1305–1315. doi: 10.1093/infdis/jiab333

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© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Enhancement of anti-HKU1 S1-RBD and anti-OC43 S1 antibody levels following COVID-19 suggests cross-reactive antibody memory response. Anti-HCoV (HKU1 S1-RBD, NL63 S1-RBD, OC43 S1, and 229E S1-RBD) antibody titers were compared between post–COVID-19 (n = 16) and prepandemic samples from children (n = 50) and adults (n = 67). Horizontal bars represent geometric mean antibody titer in each group. *P < .05, ***P < .001, ****P < .0001. Abbreviations: COVID-19, coronavirus disease 2019; HCoV, human coronavirus; IgG, immunoglobulin G; NS, not significant; RBD, receptor-binding domain; S, spike.