Table 1.
Summary of current findings on individual- and interpersonal-level interventions to support effective PrEP use
| Intervention | Study | Key findings | Potential barriers to delivery |
|---|---|---|---|
| mHealth | HPTN 082 | SMS were acceptable | SMS fatigue, smartphone access, phone data |
| MPYA | SMS reminders were ineffective in promoting PrEP adherence | ||
| PrEP SMART | Ongoing study | ||
| POWER | SMS was motivating and helped participants remember clinic visits | ||
| Drug-level feedback | HPTN 082 | Drug-level feedback counseling was not effective in increasing PrEP adherence | Drug-level feedback can be costly and logistically challenging |
| PrEP SMART | Ongoing study | ||
| Adherence counseling | EMPOWER | GBV screening and counseling acceptable and feasible | Drop-offs in retention for clinic visits, provider training and time for counseling delivery |
| PrEP SMART | Ongoing study | ||
| Peer groups | EMPOWER | Peer based club did not enhance PrEP adherence; clubs were acceptable, valuable for sharing tips on managing side effects | AGYW have busy schedules led to poor attendance of the clubs |
| HPTN 082 | Monthly adherence clubs acceptable. Approximately 70% AGYW enrolled in the trial attended at least one adherence club at three months of PrEP use | ||
| Decision support tool | POWER | AGYW who had access to the tool had 20% continuation, compared to 11% in the other website, resulting in 1.97 times the odds of PrEP continuation at month 1 than those in usual care | Limited time for completing the decision tool, smartphone access, phone data |