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. 2021 Oct 31;78(23):7469–7490. doi: 10.1007/s00018-021-04002-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Effect of the HFD in hypothalamic and plasmatic endocannabinoids, leptin levels and BAT thermogenesis during obesity progression. During HFD-induced obesity, the progressive increase of the body weight gain (green line) positively correlates with the increase of leptinemia (purple line) and circulating endocannabinoid levels (orange line). After 7 days of HFD feeding, a transient increase of hypothalamic endocannabinoid levels was observed (red line) that positively correlated with BAT thermogenesis (blue line). This early increase of hypothalamic endocannabinoids and BAT thermogenesis gradually decreases after longer periods of HFD feeding