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. 2021 Oct 31;78(23):7469–7490. doi: 10.1007/s00018-021-04002-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The endocannabinoid system in the intersection of hypothalamus-periphery cross-talk. Brain levels of 2-AG and AEA have been attributed to the higher plasma availability of arachidonic acid (ARA). The circulating pool of ARA is determined in part by FABP1 expression in the liver. Hypothalamic endocannabinoid (eCB) levels are modulated by brown adipose tissue (BAT) thermogenesis through the SNS tone, and BAT could be also acting as a

source of circulating eCB. It has also been reported that the effect of dietary fat on gut induces a positive feed-back to the brain to modulate food intake. This response is dependent on CB1 receptors