TABLE 2.

Metabolites^a of sulfur metabolism showing significantly different abundance between the dibenzothiophene and sulfate cultures

Metabolite name	Proposed function/pathway
Metabolites that were more abundant in the dibenzothiophene culture
Dibenzothiophene sulfoxide	Dibenzothiophene desulfurization, 4S pathway
Dibenzothiophene sulfone	Dibenzothiophene desulfurization, 4S pathway
O-Phosphohomoserine	Cysteine and methionine biosynthesis
O-Acetyl-l-serine	Cysteine biosynthesis
l-Histidinol	Ergothioneine biosynthesis
1-O-(2-Amino-1-deoxy-α-d-glucopyranosyl)-d-myo-inositol	Mycothiol biosynthesis
2-Iminoacetate	Thiamin/thiazole metabolism
1-Aminocyclopropane-1-carboxylic acid	S-Adenosylmethionine metabolism
5′-Deoxyadenosine	Cleavage product of S-adenosylmethionine
Coenzyme A	CoA and pantothenate biosynthesis
Metabolites that were more abundant in the inorganic sulfate culture
O-Succinyl-l-homoserine	Cysteine and methionine biosynthesis
O-Acetyl-l-homoserine	Cysteine biosynthesis
Biotin	Biotin biosynthesis
Mycothiol	Mycothiol biosynthesis
Dephospho-CoA	CoA and pantothenate biosynthesis
Cyclic pyranopterin monophosphate	Folate/molybdenum cofactor biosynthesis/sulfur relay pathways, known as precursor Z

^aMetabolites having log₂ fold change greater than 1.0 or less than −1.0. See Table S3 for more information on the metabolite abundance profile.