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. 2021 Jun 26;101(10):pzab161. doi: 10.1093/ptj/pzab161

Table 2.

Summary of Adverse Event and Dropout Reporting in Clinical Trials of Therapeutic Exercise (N = 113)a

Category Number (%)
Total number of subjects in exercise arm 5909
 Studies with a clear statement of AEs 50 (44)
 Studies that reported exercise-related AEs occurring among those subjects who were allocated to exercise 24 (21.2)
 Studies that reported exercisers experiencing an AE NOT related to exercise (among those with statement about AEs) 5 (12.5)
Total number of exercisers in studies that had a clear statement of AEs 2856
 Number of exercisers who had an exercise-related AE in exercise study arms that had a clear statement about AEs 297 (10.4)
 Number of exercisers who had an AE NOT related to exercise in studies that had a clear statement about AEs 58 (2.0)
 Studies with a clear statement of DOs 103 (91.2)
 Studies that reported DOs among studies that had a clear statement of DOs 76 (73.9)
 Studies in which reasons for DOs could be considered AEs (eg, back pain, knee pain, neck pain, leg pain, wrist pain)   among all studies that had a statement of DOs 16 (15.5)
Total number of exercisers in studies that had a clear statement of DOs 5562
 Number of exercisers who dropped out where DO reason could be considered an AE among all exercisers in studies that   reported DOs 39 (0.7)
 Number of exercisers who dropped out where DO reason was not considered harm 605 (10.9)
Total number of exercisers in studies that had a statement of AEs or a statement about DOs 5579
 Number of exercisers who dropped out where reasons for DO could be interpreted as an exercise-related AE plus total   number of exercise-related AEs reported 336 (6.0)
a

AE = adverse event; DO = dropout.