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. 2021 Sep 22;9(2):e00484-21. doi: 10.1128/Spectrum.00484-21

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Copyright © 2021 Keshavarz Azizi Raftar et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — (A) A heatmap plot of microarray data sets meta-analysis. A P value of <0.05 was considered statistically significant by Mann-Whitney method. (B) PCA plot shows separated cluster between two groups. (C) Scanning electron microscopy shows spherical morphology of EVs (magnification: ×60,000). Inhibition of HSC activation and protective effects of all A. muciniphila supplementations in LX-2 cell line. mRNA level of HSCs activation-related genes, (D) α-SMA, (E) TIMP1, (F) Col1a1, (G) TGF-β, (H) TLR-2, and (I) TLR-4, in quiescence and LPS-activated LX-2 cells. Data are expressed as mean ± standard deviation (SD) (n = 5). *, P < 0.05; **, P < 0.01; and ***, P < 0.001 by post hoc Turkey’s one-way ANOVA.