TABLE 2.
Gamhepathiopine is active against artemisinin-resistant parasitesa
| Treatment | Mean EC50 ± SD (nM)b |
P valuec | |
|---|---|---|---|
| F32-ART5 | F32-TEM | ||
| M1 | 227 ± 40 | 283 ± 125 | 0.547 |
| Artemisinin | 11 ± 0.5 | 11.1 ± 1.6 | 0.894 |
a
Chemosensitivity to M1 was determined by standard assay of asexual blood-stage P. falciparum F32-ART5 and F32-TEM lineage parasites. Artemisinin was used as the control drug.
b
Results represent the values for three independent experiments.
c
Paired t test. A P value of <0.05 was considered statistically significant.