FIG 2.

Karyotypic diversity and cross-tolerance profiles of fluconazole adaptors. Karyotypes of parent strain H99 and the 16 unique karyotypes for the 36 aneuploid isolates were visualized using YMAP (20). The chromosome copy number is indicated as a log₂ ratio relative to that of the haploid H99 reference strain on the y axis, with 1 copy at the midline, clipped to show a maximum of 2 copies. The x axis shows the positions of the reads on each chromosome, mapped relative to the chromosome of reference strain H99, and the y axis shows the numbers of adaptors bearing the same karyotypes. The concentrations of FLCs from which isolates were derived (Selection) and the FLC MICs of the adaptors are indicated in the grid to the right, along with whether these karyotypes were tolerant or not tolerant to 5FC or AMB.