TABLE 3.

Sensitivity and specificity estimates of salivary and serum assays with 95% confidence intervals

Model	Protein(s)a	Index value or % (95% CI) for:
		Saliva assay			Serum assay
		Youden’s J index	Sensitivity	Specificity	Youden’s J index	Sensitivity	Specificity
1. Random Forest	Set of 10 SARS-CoV-2 proteins	0.851	87.5 (81.6–93.6)	97.6 (92.2–100)	0.941	94.7 (89.6–98.8)	99.3 (96.1–100)
2. Random Forest	EPA_S, EPA_RBD, AB_N, PS_S2i	0.828	86.1 (80.2–91.6)	96.7 (91.9–99.3)	0.935	94.1 (89.5–97.9)	99.4 (96.6–100)
3. Logistic	EPA_S, AB_N	0.856b	87.1 (82.1–91.7)	98.5 (95.0–100)	0.959c	95.9 (92.8–98.9)	100 (98.4–100)
4. Logistic	EPA_S	0.835	85.7 (80.7–90.4)	97.8 (94.6–100)	0.940	94.7 (90.8–98.7)	99.3 (97.1–100)
5. Logistic	EPA_RBD	0.804	87.9 (79.6–93.7)	92.5 (87.2–97.6)	0.916	93.0 (88.5–97.3)	98.6 (95.2–100)
6. Logistic	AB_N	0.815	83.7 (78.9–89.2)	97.8 (94.2–99.3)	0.929	94.4 (90.5–97.8)	98.4 (96.3–100)
7. Logistic	PS_S2i	0.785	82.5 (76.6–88.0)	96.1 (91.0–99.2)	0.940	95.5 (91.5–98.8)	98.5 (94.9–100)

^aProtein IDs are defined in Results and Table 2.

^bBest value for saliva.

^cBest value for serum.