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. 2021 Oct 31;43(1):3–40. doi: 10.1007/s10072-021-05662-9

Table 6.

Summary of reported patients, who suffered from cranial nerve involvement (other than Bell’s palsy) after vaccination against SARS-CoV-2

Reference Neurological complication Country Age/sex Vaccine type Duration after vaccination Clinical features Neuroimaging Treatment Outcome
Konstantinidis et al. [99] Report of 2 patients Olfactory dysfunction Greece Both female Pfizer-BioNTech BNT162b2 3 and 5 days after second dose Hyposmia after their second dose None Olfactory training Improved
Keir et al. [100] Phantosmia USA 57/F Pfizer-BioNTech COVID-19 vaccination Second dose None Feeling weak, fatigued, with random episodes of ‘‘smelling smoke’’ associated with hyposmia Postcontrast CT demonstrates faint enhancement left olfactory tract MRI enhancement of the left greater than right olfactory bulb and bilateral olfactory tracts None None
Reyes-Capo et al. [101] Acute abducens nerve palsy USA 59/F Pfizer-BioNTech COVID-19 vaccine 2 days Fever for 1 day followed by diplopia Normal MRI of brain and orbits Not available Sensory-motor examination remained unchanged in recent follow-up
Parrino et al. [102] Tinnitus Italy 37/F 63/ 30/M BNT162b2 mRNA-vaccine 7-h first dose 20 h 7 days Sudden unilateral tinnitus Normal MRI Corticosteroids, in two Improved all
Tseng et al. [103 ] PMID: 34,297,133 Reversible tinnitus and cochleopathy Taiwan 32/M First dosage of the AstraZeneca COVID-19 vaccine 5 h High-pitch tinnitus and disturbed the normal hearing high fever with chills and myalgia Not done Corticosteroids Improved
Narasimhalu et al. [104] Trigeminal and cervical radiculitis Singapore 52/F Pfizer-BioNTech vaccination (tozinameran) 3 h first dose Numbness, swelling and pain over the left face and neck MRI of trigeminal nerve revealed thickening and perineural sheath enhancement of the V3 segment of the left trigeminal nerve The MRI of the cervical spine revealed spondylotic changes Pregabalin Improved