. Author manuscript; available in PMC: 2021 Oct 31.

Published in final edited form as: Cancer Prev Res (Phila). 2020 Oct 23;14(2):215–222. doi: 10.1158/1940-6207.CAPR-20-0348

Table 4:

Cancers reported in the JPS cohort

Gene	P/LP Variant	Age of cancer diagnosis (years)	Type of cancer
BMPR1A	c.1433G>A	26	Colon
	c.44_47delTGTT	68	Pancreas
	c.182G>A	44	Rectosigmoid
SMAD4	c.372_373dupTA	45;64	Gastric; Colon
	c.692dupG	29	Gastric
	c.692dupG	39	Cervical
	c.692dupG	46	Esophageal
	c.1507_1508insATCC	44	Breast cancer
	c.1206dupT	24	Colon
	c.1447+2T>C	48	Papillary thyroid cancer
	c.403C>T	39	Colon
	c.1308+2T>G	47	Colon
	c.1231_1232delAG	28	Colon
	c.1245_1248delGACA	15	Gastric
No disease-causing variant	NA	55	Colon
No disease-causing variant	NA	34	Bladder

Bolded cancers were considered within the JPS spectrum