Table 2.
Renal characteristics and outcomes
| All (n = 1248) | No AKI (n = 761) | All AKI (n = 487) | AKI 1 (n = 248) | AKI 2 (n = 64) | AKI 3 (n = 175) | pb | pc for trend | |
|---|---|---|---|---|---|---|---|---|
|
Baseline Cr (μmol/l), Median (IQR) |
81.0 (66.0, 99.0) | 77.0 (64.0, 92.0) | 91.0 (72.0, 116.5) | 95.0 (75.0, 121.8) | 85.0 (70.0, 118.2) | 85.0 (70.0, 106.0) | < 0.001 | < 0.001 |
|
Baseline eGFR (ml/min/1.73m2),Median (IQR) |
79.0 (61.4, 97.7) | 82.7 (68.5, 100.7) | 69.8 (48.2, 90.8) | 64.4 (44.9, 85.9) | 63.4 (50.2, 101.8) | 77.5 (59.7, 96.8) | < 0.001 | < 0.001 |
|
Admission (μmol/l), Median (IQR) |
91.0 (71.0, 126.5) | 80.0 (65.0, 96.0) | 132 (98.0, 207.) | 129 (101.0, 176.0) | 184(117.2, 261.5) | 121(87.5, 242.5) | < 0.001 | < 0.001 |
|
Peak Cr (μmol/l), Median (IQR) |
98.0 (74.8, 162.0) | 81.0 (66.0, 97.0) | 199.0 (134.0, 367.5) | 140 (114.8, 185.8) | 203.5 (165.5, 275.5) | 462.(285.5, 631.0) | < 0.001 | < 0.001 |
|
Urine proteina (n = 287) |
123 (42.9%) | 53 (35.3%) | 70 (51.1%) | 26 (38.2%) | 13 (68.4%) | 31 (62.0%) | 0.007 | < 0.001 |
|
Urine RBCsa (n = 331) |
129 (39.0%) | 58 (33.0%) | 71 (45.8%) | 31 (39.2%) | 14 (66.7%) | 26 (47.3%) | 0.017 | 0.011 |
| RRT,n (%) | 109 (8.7%) | n/a | 109 (22.4%) | 0 (0.0%) | 0 (0.0%) | 109 (62.3%) | < 0.001 | < 0.001 |
| RRT modality,n (%) | ||||||||
| CVVHDF | 63 (5.0%) | n/a | 63 (12.9%) | n/a | n/a | 63 (36.0%) | ||
| CVVHDF/HD | 12 (1.0%) | n/a | 12 (2.5%) | n/a | n/a | 12 (6.9%) | ||
| CVVHDF/PD | 26 (2.1%) | n/a | 26 (5.3%) | n/a | n/a | 26 (14.9%) | ||
| CVVHDF/PD/HD | 4 (0.3%) | n/a | 4 (0.8%) | n/a | n/a | 4 (2.3%) | ||
| HD | 4 (0.3%) | n/a | 4 (0.8%) | n/a | n/a | 4 (2.3%) | ||
| None | 1139 (91.3%) | n/a | 378 (77.6%) | n/a | n/a | 66 (37.7%) | ||
|
RRT off ICU, n (%) |
14 (1.1%) | n/a | 14 (2.9%) | n/a | n/a | 14 (8.0%) | ||
|
RRT after discharge, n (%) |
0 (0.0%) | n/a | 0 (0.0%) | n/a | n/a | 0 (0.0%) | ||
| Discharge Cr (μmol/l), Mean (SD) | 80.0 (63.0, 114.0) | 70.0 (58.0, 85.0) | 124.0 (81.5, 212.5) | 105.0 (79.0, 160.0) | 148.0 (73.0, 202.0) | 186.0 (96.0, 359.0) | < 0.001 | < 0.001 |
|
Cr recovered to baseline, n (%) (alive patients only n = 915) |
n/a | n/a | 219 (84.6%) | 143 (89.9%) | 24 (85.7%) | 52 (72.2%) | < 0.001 | |
| Admission outcome, n (%) | ||||||||
| Death in hospital | 348 (27.9%) | 132 (17.3%) | 216 (44.4%) | 89 (35.9%) | 35 (54.7%) | 92 (52.6%) | < 0.001 | < 0.001 |
| Discharged alive | 900 (72.1%) | 629 (82.7%) | 271 (55.6%) | 159 (64.1%) | 29 (45.3%) | 83 (47.4%) | < 0.001 | < 0.001 |
AKI acute kidney injury, Cr creatinine, IQR interquartile range, eGFR estimated glomerular filtration rate, ICU intensive care unit, RBCs red blood cells, RRT renal replacement therapy; CVVHDF continuousveno-venous haemodiafiltration, HD haemodialysis, PD peritoneal dialysis, SD standard deviation
ain urine dip
bcomparison between AKI vs non-AKI
ccomparison across AKI stage subgroups