Table 2.

Comparison Between the Effect of Extranasal and Intranasal Stimulation on Change from Baseline in Schirmer Test Scores in All Participants and by Subgroups

		Sjögren Syndrome Medication Use		Baseline Schirmer Score (mm/5 min)
Change from baseline in Schirmer test score	All participants (n=70 eyes)	Yes (n=52 eyes)	No (n=18 eyes)	<5 (n=17 eyes)	≥5 (n=53 eyes)
Extranasal stimulation: Mean (SE) (mm/5 min)	0.8 (0.8)	1.5 (1.1)	−1.1 (0.8)	2.9 (1.3)	−0.5 (1.0)
Intranasal stimulation: Mean (SE) (mm/5 min)	13.5 (1.6)	14.3 (1.9)	11.1 (2.5)	14.8 (2.8)	12.6 (1.8)
Difference (95% CI) (mm/5 min)	−12.7 (−15.1, −10.2)	−12.8 (−15.8, −9.8)	−12.2 (−16.2, −8.2)	−11.9 (−16.7, −7.2)	−13.1 (−15.8, −10.4)
P-value	<0.0001	<0.0001	0.007	0.004	<0.0001