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. 2021 Sep 6;28(9):909–921. doi: 10.1089/cmb.2020.0627

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© Sunil Thomas, 2021. Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License [CC-BY-NC] (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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FIG. 1. — The topology of Orf1ab (snake diagram) determined using Protter. The Orf1ab is cleaved into 16 nsps. Analysis of the Orf1ab shows the three transmembrane nsps—nsp3, nsp4, and nsp6. The 12 transmembrane domains of the nsps are shown in Figures 2–4. nsps, nonstructural proteins.