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. 2021 Sep 6;28(9):909–921. doi: 10.1089/cmb.2020.0627

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© Sunil Thomas, 2021. Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License [CC-BY-NC] (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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FIG. 3. — The topology of nsp4 of SARS-CoV-2. (A) Topology of nsp4 is determined using Protter. (B) The domains (cytoplasmic, transmembrane, and luminal) of nsp4. (C) The predicted nsp4 structure of SARS-CoV-2 (ribbon diagram) determined using the software I-TASSER. The Orf1ab is cleaved into 16 nsps. The domains (3–6) of nsp4 denote the transmembrane domain 3–6 of Orf1ab. (D) TMHMM of nsp4. (E) SOSUI predicted the membrane has four transmembrane helices. (F) CELLO prediction of the nature of the nsp4 protein.

FIG. 3. — The topology of nsp4 of SARS-CoV-2. (A) Topology of nsp4 is determined using Protter. (B) The domains (cytoplasmic, transmembrane, and luminal) of nsp4. (C) The predicted nsp4 structure of SARS-CoV-2 (ribbon diagram) determined using the software I-TASSER. The Orf1ab is cleaved into 16 nsps. The domains (3–6) of nsp4 denote the transmembrane domain 3–6 of Orf1ab. (D) TMHMM of nsp4. (E) SOSUI predicted the membrane has four transmembrane helices. (F) CELLO prediction of the nature of the nsp4 protein.