Table 1.
Desensitization Protocol for Micafungin
| Micafungin | 150 mg | IV Q24h | |||
|---|---|---|---|---|---|
| Full dose | 150 | mg | Total mg in each bag | ||
| Solution 1 | 250 | mL of | 0.006 | mg/mL | 1.500 |
| Solution 2 | 250 | mL of | 0.060 | mg/mL | 15.000 |
| Solution 3 | 250 | mL of | 0.595 | mg/mL | 148.820 |
| Step | Solution | Rate (mL/h) | Time (min) | Administered dose (mg) | Cumulative dose (mg) |
|---|---|---|---|---|---|
| 1 |
1 |
2 |
15 |
0.0030 |
0.0030 |
| 2 |
1 |
5 |
15 |
0.0075 |
0.0105 |
| 3 |
1 |
10 |
15 |
0.0150 |
0.0255 |
| 4 |
1 |
20 |
15 |
0.0300 |
0.0555 |
| 5 |
2 |
5 |
15 |
0.0750 |
0.1305 |
| 6 |
2 |
10 |
15 |
0.1500 |
0.2805 |
| 7 |
2 |
20 |
15 |
0.3000 |
0.5805 |
| 8 |
2 |
40 |
15 |
0.6000 |
1.1805 |
| 9 |
3 |
10 |
15 |
1.4882 |
2.6687 |
| 10 |
3 |
20 |
15 |
2.9764 |
5.6451 |
| 11 |
3 |
40 |
15 |
5.9528 |
11.5979 |
| 12 |
3 |
75 |
186 |
138.4021 |
150.0000 |
| Total time | 351 min | ||||