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. 2021 Nov 1;197:113762. doi: 10.1016/j.bios.2021.113762

Fig. 3.

Fig. 3

Calibration of the immunosensor for detecting anti-SARS-CoV-2 IgG and IgM in five-fold-diluted serum samples. (a)(b) Representative CA current curves measured on five-fold-diluted serum spiked with (a) CR3022 IgG antibody and (b) CR3022 IgM antibody at different concentrations. The quasi-steady-state current at 120 s was used as the signal readout for device calibration. (c)(d) The zoomed-in views of the CA current curves in (a)(b) during 119–120 s, respectively. (e) Calibration curve of the immunosensor for IgG detection at 600 pg/mL, 6 ng/mL, 60 ng/mL, 600 ng/mL, 1.5 μg/mL, 6 μg/mL and 60 μg/mL. (f) Calibration curve of the immunosensor for IgM detection at 500 pg/mL, 5 ng/mL, 50 ng/mL, 500 ng/mL, 5 μg/mL, 25 μg/mL, and 50 μg/mL. For both IgG and IgM calibration, n = 7 for current data at non-zero concentrations, and n = 10 for current data (background signals) at the zero concentration.