Table 1.

KEGG analysis. Sex differences in over-represented pathways by mouse strain.

	Female		Male
C57BL/6J Pathway Analysis	p-value	FDR	p-value	FDR
Ubiquitin mediated proteolysis	7.67E-06	0.002	1.000	1.000
Relaxin signaling pathway	1.000	1.000	7.4E-06	0.002
Pathways in cancer	0.106	0.524	0.000168	0.027
Cholinergic synapse	0.680	0.980	0.000395	0.042
PPAR signaling pathway	0.760	1.000	0.000649	0.049
Fc gamma R-mediated phagocytosis	1.000	1.000	0.000814	0.049
Colorectal cancer	1.000	1.000	0.000908	0.048
DBA/2J Pathway Analysis	p-value	FDR	p-value	FDR
Glycosphingolipid biosynthesis	5.81E-05	0.012	0.126	0.519
Focal adhesion	7.34E-05	0.012	0.009	0.133
Insulin resistance	0.000121	0.013	1.000	1.000
TGF-beta signaling pathway	0.000306	0.020	1.000	1.000
FoxO signaling pathway	0.000378	0.020	0.006	0.131
Autophagy	0.000923	0.039	0.085	0.386
Adherens junction	0.000981	0.039	1.000	1.000
Colorectal cancer	0.035	0.198	1.21E-05	0.002
Bacterial invasion of epithelial cells	0.034	0.197	1.46E-05	0.002
Endocytosis	1.000	1.000	2.07E-05	0.002
Protein processing in endoplasmic reticulum	1.000	1.000	3.63E-05	0.003
Spliceosome	0.018	0.143	0.000511	0.033
Pancreatic cancer	0.014	0.128	0.000815	0.040
ErbB signaling pathway	0.137	0.444	0.000872	0.040

Significant expression was determined from cDNA arrays; p<0.05, n=10/per sex, strain (C57BL/6J and DBA2J) and treatment (control vs binge ethanol); 80 total cDNA arrays. The input was gene symbols.