Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Kdm6 H3K27 demethylation regulates Ngn3 expression in a sex-specific manner determined by the sex chromosome complement. In control conditions, FCG XX hypothalamic neurons express higher Ngn3 mRNA levels than XY neurons, regardless of gonadal sex. Kdm6 demethylases blockade by GSK-J4 generated a decrease in Ngn3 mRNA levels in XX and an increase in XY neurons. Data are mean ± SEM. n = 3–5 independent cultures for each genotype and treatment. *p < 0.05; **p < 0.01; ***p < 0.001
