Table 2.
Correlation between menin expression and the clinico-pathological factors of 294 ER+/HER2− breast cancer patients
| Variable | Menin low | Menin high | P* | ||
|---|---|---|---|---|---|
| No. 116 |
(%) (39.5) |
No. 178 |
(%) (60.5) |
||
| Age groups | |||||
| ≤ 50 years | 21 | (18.1) | 51 | (28.7) | 0.040 |
| > 50 years | 95 | (81.9) | 127 | (71.3) | |
| Menopausal status | |||||
| Premenopausal | 22 | (19.9) | 56 | (32.6) | 0.053 |
| Postmenopausal | 92 | (80.1) | 118 | (67.4) | |
| BMI | |||||
| ≤ 25 | 64 | (57.1) | 116 | (67.8) | 0.045 |
| > 25 | 48 | (42.9) | 55 | (32.2) | |
| T. size | |||||
| ≤ 2 cm | 62 | (53.4) | 120 | (67.4) | 0.016 |
| > 2 cm | 54 | (46.6) | 58 | (32.6) | |
| LN invasion | |||||
| No | 46 | (39.7) | 74 | (41.6) | 0.744 |
| Yes | 70 | (60.3) | 104 | (58.4) | |
| SBR grade | |||||
| Gr 1 | 16 | (13.8) | 46 | (25.8) | 0.005 |
| Gr 2 | 62 | (53.4) | 99 | (55.6) | |
| Gr 3 | 38 | (32.8) | 33 | (18.5) | |
| PR status | |||||
| Negative | 18 | (15.5) | 21 | (11.8) | 0.358 |
| Positive | 98 | (84.5) | 157 | (88.2) | |
| Breast Ca. subtype | |||||
| Luminal A | 67 | (57.8) | 130 | (73.0) | 0.006 |
| Luminal B | 49 | (42.2) | 48 | (27.0) | |
| Type of adjuvant hormonal | |||||
| Tamoxifen | 51 | (45.5) | 81 | (45.8) | 0.970 |
| AI | 61 | (54.5) | 96 | (54.2) | |
| Type of adjuvant chemo | |||||
| Anthracyclin | 51 | (96.2) | 77 | (88.5) | 0.509 |
| Anthra/Taxane | 2 | (3.8) | 9 | (10.3) | |
| Other | 0 | (0) | 1 | (1.1) | |
Bold indicates statistically significant values
*Correlation by Fisher’s exact test