Table 1.
Reviewed studies in subjects with cancer predisposition syndromes
| Authors | Study characteristics | Core protocol | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Year | No. of subjects | Study population | Country | Magnet strength | Average scanning time (min) | Contrast adm | T1 W sequence | T1 W axial | T1 W coronal | T2 W axial | T2 W coronal | T2 W FS axial | T2 W FS coronal | DWI | |
| Jasperson [18] | 2013 | 34 | Surveillance HPP (paediatric and adult) | USA | – | – | Conditional | Skull base-pelvis | Skull base-pelvis | ||||||
| Anupindi [19] | 2015 | 24 | Surveillance LFS, VHL, MHE, RTS (paediatric) | USA | 1.5, 3.0 | 72 | N | TSE | Vertex-ankle | Chest-abdomen | Vertex-ankle | Head-neck-lower limbs | Vertex-ankle | ||
| Villani [20] | 2016 | 59 | Surveillance LFS (paediatric and adult) | CAN | – | 15 | N | Vertex-toe | |||||||
| Mai [22] | 2017 | 116 | Surveillance LFS (paediatric and adult) | USA | 1.5, 3.0 | 60 | Y | GRE | Chest-abdomen-pelvis | Vertex-toe | Vertex-toe | Vertex-toe | |||
| Bojadzieva [23] | 2017 | 53 | Surveillance LFS (paediatric and adult) | USA | 1.5 | – | Y | GRE | Vertex-toe | Vertex-toe | Vertex-toe | Vertex-toe | Vertex-toe | ||
| Saya [21] | 2017 | 44 | Surveillance LFS (adult) | UK | 1.5 | 60 | N | GRE | Vertex-toe | Vertex-toe | Vertex-toe | Vertex-toe | |||
| O'Neill [24] | 2017 | 17 | Surveillance LFS (paediatric) | USA | 3.0 | 75 | N | TSE | Vertex-knee | Chest | Vertex-knee | Vertex-knee | Chest-abdomen-pelvis | ||
| Paixao [25] | 2018 | 59 | Surveillance LFS (paediatric and adult) | BRA | 1.5 | 35 | N | TSE | Vertex-toe | Vertex-toe | Vertex-toe | ||||
| Friedman [26] | 2020 | 47 | Surveillance hereditary retinoblastoma (paediatric) | USA | 1.5 | 90 | N | Unknown | Vertex-toe | Whole-body | Whole-body | Vertex-toe | Vertex-toe | ||
| Authors | Study characteristics | Extensions | Patients with suspicious cancers detected by WB-MRI (%) | Confirmed by histology | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Year | No. of subjects | Study population | Country | Dedicated brain MRI | Spine | Lower limbs | Other | ||||
| Jasperson [18] | 2013 | 34 | Surveillance HPP (paediatric and adult) | USA | Targeted on suspicious findings | 6 | 17.6 | Y | |||
| Anupindi [19] | 2015 | 24 | Surveillance LFS, VHL, MHE, RTS (paediatric) | USA | T2 | Yes | 1 | 4.2 | Y | ||
| Villani [20] | 2016 | 59 | Surveillance LFS (paediatric and adult) | CAN | Yes | Yes | Breast MRI | 8 | 13.6 | Y | |
| Mai [22] | 2017 | 116 | Surveillance LFS (paediatric and adult) | USA | Yes | Yes | Breast MRI | 5 | 4.3 | Y | |
| Bojadzieva [23] | 2017 | 53 | Surveillance LFS (paediatric and adult) | USA | Yes | T1 post C | Yes | 7 | 13.2 | Y | |
| Saya [21] | 2017 | 44 | Surveillance LFS (adult) | UK | Yes | 4 | 9.1 | Y | |||
| O'Neill [24] | 2017 | 17 | Surveillance LFS (paediatric) | USA | T2 FS | Yes | Brain FLAIR | 2 | 11.8 | N | |
| Paixao [25] | 2018 | 59 | Surveillance LFS (paediatric and adult) | BRA | Yes | 3 | 5.1 | Y | |||
| Friedman [26] | 2020 | 47 | Surveillance hereditary retinoblastoma (paediatric) | USA | T1, STIR | Yes | 2 | 4.3 | Y | ||
W weighted, FS fat saturated, Y yes, N no, GRE gradient recalled echo, TSE turbo spin echo, DWI diffusion-weighted imaging, STIR short tau inversion recovery, LFS Li Fraumeni Syndrome, HPP hereditary paraganglioma pheocromocytoma syndrome, NF neurofibromatosis, MHE Multiple Hereditary Exostoses, VHL Von Hippel Lindau Syndrome