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. 2021 Oct 12;78(21-22):7061–7080. doi: 10.1007/s00018-021-03952-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Upon 24-h induction, the HeLa-XBP1u cell line accumulates XBP1u mRNA. A The results from three independent experiments (n = 9) are plotted normalized to GAPDH and RPLP0 mRNA levels and expressed as a fold change over the noninduced cells. Error bars represent standard deviations. Significant changes (P value P < 0.05) are marked with an asterisk. The corresponding changes in unspliced XBP1 protein levels were evaluated by Western blot (B) normalized to total protein levels (C) and related noninduced control. *P < 0.05 was considered significant. The exogenous XBP1u expression does not lead to the accumulation of XBP1s (D) and DNAJB9 (E) mRNA. The results from three independent experiments (n = 9) are plotted normalized to GAPDH and RPLP0 mRNA levels and expressed as a fold change over the noninduced cells. Error bars represent standard deviations. Significant changes (P value P < 0.05) are marked with an asterisk