Table 5.
Tissue concentrations of FF and FFA for goats treated intramuscularly with FF (single group) and for goats treated with FF plus DOX (combined group).
| Tissue |
Group
Single: 20 mg FF/kg bw, at 48 h intervals, twice in total |
Time after last dose (days) | FF (μg/kg) | FFA (μg/kg) | FF+FFA (μg/kg) |
|---|---|---|---|---|---|
| Combined: 20 mg FF/kg bw, at 48 h intervals, twice in total plus 10 mg DOX/kg bw, once a day for 3 days | |||||
| Liver | Single | 0.5 | 2791.1 ± 256.7 | 1715.0 ± 284.7 | 4618.5 ± 188.0 |
| 1 | 2053.8 ± 310.5 | 1324.0 ± 234.8 | 3377.8 ± 155.6 | ||
| 3 | 936.2 ± 148.3 | 827.0 ± 136.8 | 1763.2 ± 76.1 | ||
| 7 | 338.4 ± 126.3 | 678.2 ± 77.1 | 1005.4 ± 67.8 | ||
| 14 | 178.7 ± 26.5 | 294.1 ± 41.6 | 472.8 ± 46.0 | ||
| 21 | 44.5 ± 17.6 | 88.5 ± 26.6 | 133.0 ± 41.8 | ||
| Combined | 0.5 | 2904.7 ±195.7 | 1687.5 ± 305.5 | 4592.2 ± 480.0 | |
| 1 | 2181.0 ± 189.1 | 1264.1 ± 133.5 | 3445.1 ± 173.6 | ||
| 3 | 937.1 ± 193.3 | 858.0 ± 93.7 | 1795.1 ± 173.6 | ||
| 7 | 342.4 ± 69.9 | 630.4 ± 110.5 | 972.8 ± 52.1 | ||
| 14 | 204.4 ± 52.1 | 329.2 ± 52.4 | 533.5 ± 33.0 | ||
| 21 | 62.6 ± 19.5 | 113.0 ± 15.3 | 175.6 ± 6.8 | ||
| Kidney | Single | 0.5 | 2259.8 ± 203.0 | 1297.1 ± 239.3 | 3556.9 ± 209.3 |
| 1 | 1772.2 ± 141.8 | 1047.9 ± 105.4 | 2820.1 ± 177.4 | ||
| 3 | 843.1 ± 123.7 | 677.1 ± 88.7 | 1520.2 ± 70.2 | ||
| 7 | 327.4 ± 43.4 | 328.5 ± 49.7 | 656.0 ± 24.2 | ||
| 14 | 130.7 ± 17.1 | 168.6 ± 33.3 | 299.3 ± 26.1 | ||
| 21 | 37.5 ± 8.6 | 62.0 ± 19.9 | 99.5 ± 27.6 | ||
| Combined | 0.5 | 2373.0 ± 250.9 | 1194.3 ± 124.9 | 3567.3 ± 201.8 | |
| 1 | 1873.8 ± 164.4 | 977.7 ± 216.4 | 2851.5 ± 178.3 | ||
| 3 | 812.2 ± 117.8 | 687.1 ± 60.2 | 1499.4 ± 66.0 | ||
| 7 | 369.3 ± 69.7 | 315.8 ± 88.2 | 685.1 ± 61.5 | ||
| 14 | 140.1 ± 46.8 | 164.8 ± 58.6 | 304.9 ± 14.0 | ||
| 21 | 50.7 ± 8.1 | 83.0 ± 20.9 | 133.7 ± 19.6 | ||
| Muscle | Single | 0.5 | 1762.3 ± 201.0 | 1083.7 ± 101.3 | 2846.1 ± 301.9 |
| 1 | 858.1 ± 43.2 | 492.6 ± 49.2 | 1350.7 ± 64.0 | ||
| 3 | 376.2 ± 58.1 | 322.7 ± 72.8 | 698.9 ± 35.6 | ||
| 7 | 162.1 ± 4.6 | 107.5 ± 11.9 | 269.6 ± 16.4 | ||
| 14 | 48.6 ± 7.6 | 68.1 ± 13.4 | 116.7 ± 20.9 | ||
| 21 | ND | ND | ND | ||
| Combined | 0.5 | 1701.1 ± 111.2 | 862.4 ± 103.4 | 2563.5 ± 212.1 | |
| 1 | 920.5 ± 69.2 | 479.2 ± 29.8 | 1399.6 ± 69.7 | ||
| 3 | 420.5 ± 31.8 | 265.6 ± 65.7 | 686.1 ± 50.1 | ||
| 7 | 170.0 ± 23.6 | 97.0 ± 25.3 | 267.1 ± 7.9 | ||
| 14 | 50.6 ± 3.7 | 62.3 ± 5.7 | 112.9 ± 8.9 | ||
| 21 | ND | ND | ND |
Each value is the mean ± SD for 4 goats.