Table 2.

Overview of the typical CRAC channel hallmarks of STIM1 mutants

	Without STIM1	STIM1	STIM1 Δα2	STIM1 F394A	STIM1 F394H	STIM1 F394D
Vrev [mV]
Orai1	–	59.22 ± 5.92	43.85 ± 4.35	57.00 ± 5.59	55.60 ± 7.45	–
Orai1 P245L	33.4 ± 1.88	40.16 ± 5.3	46.52 ± 9.81	41.39 ± 5.69	40.05 ± 9.39	43.27 ± 1.98
Orai1 V102A	32.58 ± 1.85	49.31 ± 3.31	31.63 ± 4.71	46.70 ± 10.98	58.10 ± 2.97	27.41 ± 4.83
FCDI
Orai1 P245L	–	Yes	No	Yes	No	No
IDVF:ICa2+
Orai1 P245L	0.5	5.5	2.7	2.1	0.6	2.2

Table summarizes the V_rev, FCDI and the ratio I_DVF:I_Ca²⁺ of Orai1 and Orai1 P245L currents in the absence of STIM1 and the presence of STIM1, STIM1 Δα2, STIM1 F394A, STIM1 F394H and STIM1 F394D. Moreover, the V_rev of Orai1 V102A currents in the absence of STIM1 and the presence of STIM1, STIM1 Δα2, STIM1 F394A, STIM1 F394H and STIM1 F394D are listed