Table 3.

Variables associated with strain in the patient group; univariate and multivariable analyses.

		Univariate analysisb		Multivariable analysisc
Variable	N	Mean ± SD or β (SE)	P	Adjusted mean (SE) or β (SE)	P
Age (years)	90	−0.086 (0.058)	0.143	0.043 (0.094)	0.646
Sex (m/f)			0.031*		0.020*
Male	41	21.46 ± 2.59		21.89 (0.75)
Female	49	20.21 ± 2.78		20.56 (0.72)
BMI, kg/m2	90	−0.151 (0.071)	0.036*	−0.215 (0.068)	0.002*
Follow-up time (years)	90	−0.106 (0.048)	0.029*	−0.199 (0.088)	0.027*
Cardiac risk group			0.491		0.222
No risk	5	21.68 ± 2.48		23.83 (1.83)
Low	4	19.70 ± 3.39		20.48 (1.41)
Intermediate	47	21.08 ± 2.94		20.94 (0.51)
High	34	20.37 ± 2.46		19.64 (0.64)
Cumulative anthracycline dose,a mg/m2	90	−0.001 (0.003)	0.727	0.002 (0.005)	0.619
Chest radiotherapy			0.004*		0.370
No	70	21.22 ± 2.50		21.57 (0.59)
Yes	20	19.26 ± 3.11		20.87 (0.93)
Hypertension			0.291		0.527
Normal	63	20.96 ± 2.91		21.43 (0.70)
High	26	20.27 ± 2.33		21.03 (0.78)

^*Indicates statistically significant.

β indicates regression coefficient for one-unit increase in continuous variables.

^aDoxorubicin isotoxic equivalents.

^bThe means between two groups were compared with the independent samples t-test and between cardiac risk groups with the one-way ANOVA.

Linear regression was used to evaluate the association of continuous variable with strain.

^cMultivariable linear model.